Discovery platform for inhibitors of IgH gene enhancer activity
نویسندگان
چکیده
منابع مشابه
Evidence for transient requirement of the IgH enhancer.
A transcriptional enhancer is thought to play a major role in determining tissue-specific expression of the immunoglobulin heavy chain (IgH) gene (1-3). However in three B-lymphoid cell lines the Ig enhancer has been lost due to a spontaneous deletion, yet heavy chain synthesis persists at a high level (4-6). In the case of the enhancerless delta chain gene (5) we wanted to test whether the IgH...
متن کاملRole of OCA-B in 3'-IgH enhancer function.
OCA-B (alternately called Bob1 and OBF-1) is a B cell-specific coactivator that interacts with the ubiquitously expressed Oct-1 and the B cell-restricted Oct-2 to activate transcription via the octamer site (5'-ATGCAAAT-3'). OCA-B-/- mice appear to undergo normal Ag-independent B cell maturation. However, Ag-dependent B cell differentiation, including germinal center formation, production of se...
متن کاملElucidation of IgH intronic enhancer functions via germ-line deletion.
Studies of chimeric mice demonstrated that the core Ig heavy chain (IgH) intronic enhancer (iEmu) functions in V(D)J and class switch recombination at the IgH locus. To more fully evaluate the role of this element in these and other processes, we generated mice homozygous for germ-line mutations in which the core sequences of iEmu (cEmu) were either deleted (cEmu(Delta/Delta) mice) or replaced ...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2018
ISSN: 1538-4047,1555-8576
DOI: 10.1080/15384047.2018.1538615